P.052 Trazodone for treating insomnia: abuse and safety risks
نویسندگان
چکیده
Background: Although unapproved by the FDA for treating insomnia, trazodone is commonly prescribed in US partly due to lack of scheduling, hence it’s perceived as safer than z-drugs and benzodiazepines. This study investigated abuse/dependence potential safety risks. Methods: Cases involving or benzodiazepines (temazepam, triazolam, estazolam) frequently insomnia were identified from Adverse Events Reporting System (FAERS), National Forensic Laboratory Information (NFLIS) confiscation data, American Association Poison Control Centers’-National Data (AAPCC-NPDS). Drug-related falls risk was assessed claims databases. Results: FAERS included 11,228 5120 benzodiazepine reports. Of these, drug-abuse drug-dependence cases with lower (drug-abuse: 6.4%/12.6%; drug-dependence: 1.1%/3.6%). Serious (81.8%/83.9%) deaths (35.4%/36.0%), similar between NFLIS reported 612/1,575,874 (0.04%) drug-seizure that trazodone. AAPCC-NPDS 22,225/1,446,011 (1.54%) total case mentions trazodone/all pharmaceuticals 8445 trazodone-related single-exposure cases. Falls (1year-period) Medicare beneficiaries ≥65y commercially-insured enrollees ≥18y benzodiazepines: Medicare, 9.5%/11.3%; Commercially-insured: 4.6%/3.7%. Conclusions: Trazodone has important Given limited data well-controlled studies off-label use, re-evaluation prescribing rates patients warranted.
منابع مشابه
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences
سال: 2023
ISSN: ['2057-0155', '0317-1671']
DOI: https://doi.org/10.1017/cjn.2023.156